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Active GLP-1 use also introduces medication metabolites into the plasma pool
Involvement of L-carnitine in cellular metabolism: beyond Acyl-CoA transport
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Most previous studies exhibit three key limitations: (1) insufficient depth and breadth in mechanistic and target exploration, with unsystematic examination of the potential of metabolites, (2) incomplete evidence systems, marked by an over-reliance on preclinical data and a lack of clinical validation, and (3) weak dialectical analysis, particularly in the dynamic evaluation of the dual effects of metabolites across pathophysiological contexts
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